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Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies.
Williams WB, Meyerhoff RR, Edwards RJ, Li H, Manne K, Nicely NI, Henderson R, Zhou Y, Janowska K, Mansouri K, Gobeil S, Evangelous T, Hora B, Berry M, Abuahmad AY, Sprenz J, Deyton M, Stalls V, Kopp M, Hsu AL, Borgnia MJ, Stewart-Jones GBE, Lee MS, Bronkema N, Moody MA, Wiehe K, Bradley T, Alam SM, Parks RJ, Foulger A, Oguin T, Sempowski GD, Bonsignori M, LaBranche CC, Montefiori DC, Seaman M, Santra S, Perfect J, Francica JR, Lynn GM, Aussedat B, Walkowicz WE, Laga R, Kelsoe G, Saunders KO, Fera D, Kwong PD, Seder RA, Bartesaghi A, Shaw GM, Acharya P, Haynes BF. Williams WB, et al. Among authors: walkowicz we. Cell. 2021 May 27;184(11):2955-2972.e25. doi: 10.1016/j.cell.2021.04.042. Epub 2021 May 20. Cell. 2021. PMID: 34019795 Free PMC article.
Semisynthesis of Analogues of the Saponin Immunoadjuvant QS-21.
Fernández-Tejada A, Walkowicz WE, Tan DS, Gin DY. Fernández-Tejada A, et al. Among authors: walkowicz we. Methods Mol Biol. 2017;1494:45-71. doi: 10.1007/978-1-4939-6445-1_4. Methods Mol Biol. 2017. PMID: 27718185 Free PMC article.
Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Bonsignori M, Kreider EF, Fera D, Meyerhoff RR, Bradley T, Wiehe K, Alam SM, Aussedat B, Walkowicz WE, Hwang KK, Saunders KO, Zhang R, Gladden MA, Monroe A, Kumar A, Xia SM, Cooper M, Louder MK, McKee K, Bailer RT, Pier BW, Jette CA, Kelsoe G, Williams WB, Morris L, Kappes J, Wagh K, Kamanga G, Cohen MS, Hraber PT, Montefiori DC, Trama A, Liao HX, Kepler TB, Moody MA, Gao F, Danishefsky SJ, Mascola JR, Shaw GM, Hahn BH, Harrison SC, Korber BT, Haynes BF. Bonsignori M, et al. Among authors: walkowicz we. Sci Transl Med. 2017 Mar 15;9(381):eaai7514. doi: 10.1126/scitranslmed.aai7514. Sci Transl Med. 2017. PMID: 28298420 Free PMC article.
Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.
Alam SM, Aussedat B, Vohra Y, Meyerhoff RR, Cale EM, Walkowicz WE, Radakovich NA, Anasti K, Armand L, Parks R, Sutherland L, Scearce R, Joyce MG, Pancera M, Druz A, Georgiev IS, Von Holle T, Eaton A, Fox C, Reed SG, Louder M, Bailer RT, Morris L, Abdool-Karim SS, Cohen M, Liao HX, Montefiori DC, Park PK, Fernández-Tejada A, Wiehe K, Santra S, Kepler TB, Saunders KO, Sodroski J, Kwong PD, Mascola JR, Bonsignori M, Moody MA, Danishefsky S, Haynes BF. Alam SM, et al. Among authors: walkowicz we. Sci Transl Med. 2017 Mar 15;9(381):eaai7521. doi: 10.1126/scitranslmed.aai7521. Sci Transl Med. 2017. PMID: 28298421 Free PMC article.
Vaccine Elicitation of High Mannose-Dependent Neutralizing Antibodies against the V3-Glycan Broadly Neutralizing Epitope in Nonhuman Primates.
Saunders KO, Nicely NI, Wiehe K, Bonsignori M, Meyerhoff RR, Parks R, Walkowicz WE, Aussedat B, Wu NR, Cai F, Vohra Y, Park PK, Eaton A, Go EP, Sutherland LL, Scearce RM, Barouch DH, Zhang R, Von Holle T, Overman RG, Anasti K, Sanders RW, Moody MA, Kepler TB, Korber B, Desaire H, Santra S, Letvin NL, Nabel GJ, Montefiori DC, Tomaras GD, Liao HX, Alam SM, Danishefsky SJ, Haynes BF. Saunders KO, et al. Among authors: walkowicz we. Cell Rep. 2017 Feb 28;18(9):2175-2188. doi: 10.1016/j.celrep.2017.02.003. Cell Rep. 2017. PMID: 28249163 Free PMC article.
Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates.
Francica JR, Laga R, Lynn GM, Mužíková G, Androvič L, Aussedat B, Walkowicz WE, Padhan K, Ramirez-Valdez RA, Parks R, Schmidt SD, Flynn BJ, Tsybovsky Y, Stewart-Jones GBE, Saunders KO, Baharom F, Petrovas C, Haynes BF, Seder RA. Francica JR, et al. Among authors: walkowicz we. PLoS Biol. 2019 Jun 17;17(6):e3000328. doi: 10.1371/journal.pbio.3000328. eCollection 2019 Jun. PLoS Biol. 2019. PMID: 31206510 Free PMC article.
Cooperation between somatic mutation and germline-encoded residues enables antibody recognition of HIV-1 envelope glycans.
Wu NR, Nicely NI, Lee EM, Reed RK, Watts BE, Cai F, Walkowicz WE, Aussedat B, Jones JA, Eaton A, Trama AM, Alam SM, Montefiori DC, Haynes BF, Saunders KO. Wu NR, et al. Among authors: walkowicz we. PLoS Pathog. 2019 Dec 16;15(12):e1008165. doi: 10.1371/journal.ppat.1008165. eCollection 2019 Dec. PLoS Pathog. 2019. PMID: 31841553 Free PMC article.